Phenotypes Associated with This Genotype

Genotype
MGI:5519891

• Allelic Composition: Edn2^tm1Ywa/Edn2^tm1Ywa
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decreased body weight in Edn2^tm1Ywa/Edn2^tm1Ywa mice

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:201436 )

• when housed at 22 degrees Celsius

premature death ( J:201436 )

• mice die by 3 to 4 weeks of age

• not rescued by thyroid hormone replacement

• however, mice housed at a higher temperature exhibit extended lifespan to 9 weeks

postnatal lethality, incomplete penetrance ( J:201436 )

• mice die by 3 to 4 weeks of age

• not rescued by thyroid hormone replacement

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:201436 )

N • mice exhibit normal serum insulin levels and secretion

impaired adaptive thermogenesis ( J:201436 )

• decreased body temperature in response to cold exposure

• mice exhibit a preference for a warmer temperature location than wild-type mice

abnormal blood homeostasis ( J:201436 )

acidemia ( J:201436 )

• blood pH is more acidic

increased blood urea nitrogen level ( J:201436 )

increased blood uric acid level ( J:201436 )

increased circulating bicarbonate level ( J:201436 )

decreased circulating glucose level ( J:201436 )

• under fed conditions

increased circulating erythropoietin level ( J:201436 )

decreased circulating triiodothyronine level ( J:201436 )

• mild

increased circulating ketone body level ( J:201436 )

decreased body temperature ( J:201436 )

• mild hypothermia

abnormal gas homeostasis ( J:201436 )

hypercapnia ( J:201436 )

hypoxia ( J:201436 )

• hypoxemic hypoxia

acidosis ( J:201436 )

• blood pH is more acidic

abnormal lipolysis ( J:201436 )

• cold-exposed mice fail to exhibit enhanced lipolysis unlike wild-type mice

growth/size/body

decreased body size ( J:201436 )

• at 2 weeks

decreased body weight ( J:201436 )

• beginning at P5

postnatal growth retardation ( J:201436 )

• severe by P5

• not rescued by thyroid hormone replacement

respiratory system

abnormal pulmonary alveolar sac morphology ( J:201436 )

abnormal pulmonary alveolus morphology ( J:201436 )

• simplified structure

increased total lung capacity ( J:201436 )

adipose tissue

abnormal brown adipose tissue morphology ( J:201436 )

• reduced nuclei number and increased large lipid vacuoles in cold-exposed mice

digestive/alimentary system

digestive/alimentary phenotype ( J:201436 )

N • mice exhibit normal fat and carbohydrate absorption and excretion

hematopoietic system

increased hematocrit ( J:201436 )