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Phenotypes Associated with This Genotype
Genotype
MGI:5519099
Allelic
Composition
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background
involves: 129 * 129P2/OlaHsd * C57BL/6J * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53tm1Brn mutation (21 available); any Trp53 mutation (249 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die from around 250 to 375 days of age

neoplasm
• tumors show metastasis, most frequently to the lung and then the liver
• complete penetrance of osteosarcomas with an average latency of 292 days

skeleton
• complete penetrance of osteosarcomas with an average latency of 292 days


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory