Phenotypes Associated with This Genotype

Genotype
MGI:5518941

• Allelic Composition: Trp53^tm1.1Thst/Trp53^tm1.1Thst
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:198482 )

• median survival is 361 days compared with over 770 days for wild-type mice

neoplasm

increased tumor incidence ( J:198482 )

• mice develop fewer hematological malignancy compared with Trp53^tm1Thst homozygotes

increased T cell derived lymphoma incidence ( J:198482 )

• in most mice

increased leiomyosarcoma incidence ( J:198482 )

• in some mice

increased carcinoma incidence ( J:198482 )

• in some mice

increased hemangiosarcoma incidence ( J:198482 )

• in some mice

immune system

immune system phenotype ( J:198482 )

N • mice exhibit normal thymic senescence staining and reactive oxygen species levels

decreased thymocyte apoptosis ( J:198482 )

• following gamma irradiation

• however, apoptosis response to dexamethasone is normal

increased T cell derived lymphoma incidence ( J:198482 )

• in most mice

spleen hyperplasia ( J:198482 )

• nonmalignant in most mice

cellular

abnormal cell physiology ( J:198482 )

• mouse embryonic fibroblasts infected with retroviruses expressing E1A and HRas^G12V exhibit increased tumor growth when injecgted subcutaneously in immunocompromised mice and tumors do not exhibit increased apoptosis after chemotherapy compared with when wild-type cells are used

decreased cellular sensitivity to gamma-irradiation ( J:198482 )

• following whole body gamma irradiation, mice are resistant to apoptosis in the thymus, developing cerebellum and intestinal crypt compared with wild-type mice

decreased thymocyte apoptosis ( J:198482 )

• following gamma irradiation

• however, apoptosis response to dexamethasone is normal

hematopoietic system

decreased thymocyte apoptosis ( J:198482 )

• following gamma irradiation

• however, apoptosis response to dexamethasone is normal

increased T cell derived lymphoma incidence ( J:198482 )

• in most mice

spleen hyperplasia ( J:198482 )

• nonmalignant in most mice

endocrine/exocrine glands

decreased thymocyte apoptosis ( J:198482 )

• following gamma irradiation

• however, apoptosis response to dexamethasone is normal

increased T cell derived lymphoma incidence ( J:198482 )

• in most mice

growth/size/body

spleen hyperplasia ( J:198482 )

• nonmalignant in most mice

muscle

increased leiomyosarcoma incidence ( J:198482 )

• in some mice

homeostasis/metabolism

decreased cellular sensitivity to gamma-irradiation ( J:198482 )

• following whole body gamma irradiation, mice are resistant to apoptosis in the thymus, developing cerebellum and intestinal crypt compared with wild-type mice