Phenotypes Associated with This Genotype

Genotype
MGI:5518647

• Allelic Composition: Sox11^tm1.1Gan/Sox11^tm1.1Gan; Tg(Six3-cre)69Frty/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Decrease in retinal ganglion cells in single Sox11^tm1.1Gan and Sox4^tm1Vlf homozygous conditional mutants and abolishment of retinal ganglion cells in Sox11^tm1.1Gan/Sox11^tm1.1Gan Sox4^tm1Vlf/Sox4^tm1Vlf Tg(Six3-cre)69Frty/0 retinas

vision/eye

vision/eye phenotype ( J:199663 )

N • mice exhibit normal numbers of horizontal, Muller glial, cone and rod cells

increased retina apoptosis ( J:199663 )

• 2-fold increase starting at E14.5

optic nerve hypoplasia ( J:199663 )

• thin

abnormal eye development ( J:199663 )

• impaired retinal ganglion cell development

abnormal retina morphology ( J:199663 )

• reduced number of axon bundles in the retina

decreased amacrine cell number ( J:199663 )

• in the inner nuclear layer and ganglion cell layer

decreased retina ganglion cell number ( J:199663 )

• beginning from E12.5 to E16.5

• moderate at P0 and in adult mice

abnormal retina bipolar cell morphology ( J:199663 )

• decreased number

thin retina ganglion layer ( J:199663 )

thin retina inner nuclear layer ( J:199663 )

growth/size/body

decreased birth weight ( J:199663 )

• moderate

• however, mice exhibit normal body weight and size by P30

cellular

increased retina apoptosis ( J:199663 )

• 2-fold increase starting at E14.5

abnormal axon fasciculation ( J:199663 )

• reduced in retinal axon bundles

nervous system

abnormal axon fasciculation ( J:199663 )

• reduced in retinal axon bundles

decreased amacrine cell number ( J:199663 )

• in the inner nuclear layer and ganglion cell layer

decreased retina ganglion cell number ( J:199663 )

• beginning from E12.5 to E16.5

• moderate at P0 and in adult mice

abnormal retina bipolar cell morphology ( J:199663 )

• decreased number

optic nerve hypoplasia ( J:199663 )

• thin