mortality/aging
• mice die immediately after birth
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digestive/alimentary system
• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5
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• at E18.5, mice exhibit fewer mesenchyme cells between thin layers of mesentery and intestinal epithelium compared with control mice
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• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5
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• decreased SMA+ or Desmin+ intestinal smooth muscle cells
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• absent intestinal mesenchymal proliferation
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• intestinal epithelium do not proliferate at E18.5
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muscle
• decreased SMA+ or Desmin+ intestinal smooth muscle cells
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cellular
• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5
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• intestinal epithelium do not proliferate at E18.5
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nervous system
• decreased population
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