Phenotypes Associated with This Genotype

Genotype
MGI:5518634

• Allelic Composition: Smo^tm2Amc/Smo^tm2Amc; Nkx3-2^tm1(cre)Wez/Nkx3-2⁺
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Intestinal mesenchymal proliferation and expansion are affected in Smo^tm2Amc/Smo^tm2Amc Nkx3-2^tm1(cre)Wez/Nkx3-2⁺ embryos

mortality/aging

neonatal lethality, complete penetrance ( J:199664 )

• mice die immediately after birth

digestive/alimentary system

abnormal intestinal enteroendocrine cell morphology ( J:199664 )

• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5

abnormal intestine goblet cell morphology ( J:199664 )

• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5

abnormal intestine development ( J:199664 )

• at E18.5, mice exhibit fewer mesenchyme cells between thin layers of mesentery and intestinal epithelium compared with control mice

abnormal intestinal smooth muscle morphology ( J:199664 )

• decreased SMA+ or Desmin+ intestinal smooth muscle cells

abnormal intestine physiology ( J:199664 )

• absent intestinal mesenchymal proliferation

abnormal enterocyte proliferation ( J:199664 )

• intestinal epithelium do not proliferate at E18.5

muscle

abnormal intestinal smooth muscle morphology ( J:199664 )

• decreased SMA+ or Desmin+ intestinal smooth muscle cells

cellular

abnormal intestinal enteroendocrine cell morphology ( J:199664 )

• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5

abnormal intestine goblet cell morphology ( J:199664 )

• lack of Goblet and enteroendocrine cell lineage differentiation at E18.5

abnormal enterocyte proliferation ( J:199664 )

• intestinal epithelium do not proliferate at E18.5

nervous system

abnormal enteric neuron morphology ( J:199664 )

• decreased population