Phenotypes for Pygo1 Pygo2 MGI:5518434 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Pygo1^tm1.1Kba/Pygo1^tm1.1Kba Pygo2^tm1.1Kba/Pygo2^tm1.1Kba
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pygo1^tm1.1Kba mutation (0 available); any Pygo1 mutation (21 available)
Pygo2^tm1.1Kba mutation (0 available); any Pygo2 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

oligozoospermia ( J:198562 )

• severe depletion of mature sperm cells in the lumen of most seminiferous tubules without a change in proliferation or apoptosis in the testis

abnormal spermatid morphology ( J:198562 )

• impaired nuclear condensation of elongating spermatids

mortality/aging

mortality/aging ( J:198562 )

N	• mice are born in expected Mendelian ratios

reproductive system

oligozoospermia ( J:198562 )

• severe depletion of mature sperm cells in the lumen of most seminiferous tubules without a change in proliferation or apoptosis in the testis

abnormal spermatid morphology ( J:198562 )

• impaired nuclear condensation of elongating spermatids

male infertility ( J:198562 )

• in some mice

reduced male fertility ( J:198562 )

• in some mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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