About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5517703
Allelic
Composition
Tg(Pax6-TAg)1796Hur/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• 100% of mutants develop retinal and lens tumors by E12.5, that rapidly progress throughout fetal and postnatal life (J:196814)
• 100% of mutants develop retinal and lens tumors by E12.5, that rapidly progress throughout fetal and postnatal life (J:196814)
• retinal-derived tumors invade the choroid and metastasize through the optic nerve to the brain (J:196814)
• a subpopulation of retinal tumor cells that express CD133 are capable of forming heterogeneous tumors similar to the primary retinal tumor when transplanted in vivo (J:196814)
• retinal-derived tumors invade the choroid and metastasize through the optic nerve to the brain (J:196814)
• a subpopulation of retinal tumor cells that express CD133 are capable of forming heterogeneous tumors similar to the primary retinal tumor when transplanted in vivo (J:196814)

vision/eye
• no evidence of retinal differentiation (J:196814)
• no evidence of retinal differentiation (J:196814)

Mouse Models of Human Disease
OMIM ID Ref(s)
Retinoblastoma; RB1 180200 J:196814


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory