Mouse Genome Informatics
tg
    Tg(Pax6-TAg)1796Hur/0
involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• 100% of mutants develop retinal and lens tumors by E12.5, that rapidly progress throughout fetal and postnatal life
• retinal-derived tumors invade the choroid and metastasize through the optic nerve to the brain
• a subpopulation of retinal tumor cells that express CD133 are capable of forming heterogeneous tumors similar to the primary retinal tumor when transplanted in vivo

vision/eye
• no evidence of retinal differentiation

Mouse Models of Human Disease
OMIM IDRef(s)
Retinoblastoma; RB1 180200 J:196814