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Phenotypes Associated with This Genotype
Genotype
MGI:5517577
Allelic
Composition		 Pla2g5tm1Jarm/Pla2g5tm1Jarm
Genetic
Background		 B6.129-Pla2g5tm1Jarm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pla2g5tm1Jarm mutation (0 available); any Pla2g5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:197334 )
N
• in a model of IgE antigen-dependent passive cutaneous anaphylaxis, mice exhibit normal edema
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

hematopoietic system
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

cellular
impaired macrophage phagocytosis ( J:110309 )
• after stimulation with zymosan, peritoneal macrophages exhibit decreased phagocytosis compared with similarly treated wild-type mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory