About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:5517541
Allelic
Composition		 Ltb4r2tm1Tksh/Ltb4r2tm1Tksh
Genetic
Background		 C.Cg-Ltb4r2tm1Tksh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ltb4r2tm1Tksh mutation (2 available); any Ltb4r2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:133998 )
• bone marrow-derived mast cells fail to migrate in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) unlike wild-type cells
• however, bone marrow-derived mast cells exhibit normal migration in response to LTB4 and stem cell factor (SCF)

hematopoietic system
abnormal mast cell physiology ( J:133998 )
• bone marrow-derived mast cells fail to migrate in response to 12-12(S)-hydroxyheptadeca-5Z, 8E, 10E-trienoic acid (12-HHT) unlike wild-type cells
• however, bone marrow-derived mast cells exhibit normal migration in response to LTB4 and stem cell factor (SCF)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory