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Phenotypes Associated with This Genotype
Genotype
MGI:5517485
Allelic
Composition
Syn3tm1Pggd/Syn3tm1Pggd
Genetic
Background
B6.129X1-Syn3tm1Jfe
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn3tm1Pggd mutation (2 available); any Syn3 mutation (12 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• in the social transmission of food preference task, mutants show an absence of preference for the cued food over the novel food after one hour after social interaction with the demonstrator cagemate
• in the social dominance tube test, adults show more submissive behavior than controls
• in the social novelty test, young mutants do not discriminate between familiar and novel mice compared to controls that spend more time exploring the novel mouse than a familiar mouse indicating altered social novelty preference
• in the resident-intruder test, mutants show reduced social interaction with the intruder mice after 1-2 months of social isolation
• however, mutants exhibit normal anxiety related behaviors

taste/olfaction
N
• olfaction is intact

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:201707


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory