Mouse Genome Informatics
phenotype observed in females
phenotype observed in males
N normal phenotype
• mutants bury fewer marbles than controls when placed in a cage with new bedding and marbles and this behavior is associated with reduced time spent in digging, whereas rearing behavior is unchanged
• after habituation to marbles, mutants still bury less marbles than controls, suggesting this behavior is no due to an altered response to novelty but a decrease in interest toward the environment
• however, mutants exhibit normal anxiety related behaviors
• in the social dominance tube test, adults show more dominant behavior than controls
• young and adult mutants exhibit increased repetitive self-grooming behavior
• in the social recognition test, adults spend a similar time in exploring the intruder mouse during all sessions and both young and adult mutants do not increase the exploration of the novel intruder mouse on the fifth session, indicating defective short-term social recognition
• in a modified three-chamber social approach test, mutants exhibit reduced interest for both the social stimulus (unfamiliar stranger mouse) and the novel empty cup
• in the social novelty test, young and adult mutants do not discriminate between familiar and novel mice compared to controls that spend more time exploring the novel mouse than a familiar mouse
• in the resident-intruder test, mutants show reduced social interaction with the intruder mice after 1-2 months of social isolation

• olfaction is intact

Mouse Models of Human Disease
Autism 209850 J:201707