Phenotypes Associated with This Genotype

Genotype
MGI:5517430

• Allelic Composition: Gt(ROSA)26Sor^tm1Jus/Gt(ROSA)26Sor⁺; Tg(MMTV-cre)4Mam/0
• Genetic Background: involves: C57BL/6J * C57BL/6N * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:202090 )

• median survival is 64 days

immune system

enlarged thymus ( J:202090 )

• in diseased mice

abnormal thymus physiology ( J:202090 )

• lymphoid infiltration in the thymus at 6 months

enlarged spleen ( J:202090 )

• in diseased mice

abnormal leukocyte morphology ( J:202090 )

• monomorphic, enlarged white blood cells with a high nuclear:chromatin ratio (consistent with leukemic blasts) at 6 months

decreased pro-B cell number ( J:202090 )

arrested B cell differentiation ( J:202090 )

• nearly all B cells are arrested in the early pro-B stage

decreased double-positive T cell number ( J:202090 )

• in the thymus

decreased B cell number ( J:202090 )

• in the spleen

decreased mature B cell number ( J:202090 )

decreased pre-B cell number ( J:202090 )

increased leukocyte cell number ( J:202090 )

• at 6 months

increased CD8-positive, alpha-beta T cell number ( J:202090 )

• in the thymus

increased single-positive T cell number ( J:202090 )

• immature single positive cells in the thymus

increased large unstained cell number ( J:202090 )

• large, unstained cells (abnormal blasts) in the peripheral blood at 6 months

intermingled spleen red and white pulp ( J:202090 )

• disrupted separation between white and red pulp by infiltrating lymphoblasts at 6 months

enlarged lymph nodes ( J:202090 )

• in diseased mice

increased inflammatory response ( J:202090 )

• lymphoid infiltration in the spleen, interstitial and perivascular space of the kidney, perivascular cuffs in the liver, meninges surrounding the brain, thymus, stomach and intestine at 6 months

intestinal inflammation ( J:202090 )

• lymphoid infiltration in the intestine at 6 months

stomach inflammation ( J:202090 )

• lymphoid infiltration in the stomach at 6 months

meningitis ( J:202090 )

• lymphoid infiltration in the meninges surrounding the brain at 6 months

liver inflammation ( J:202090 )

• lymphoid infiltration in the perivascular cuffs in the liver at 6 months

kidney inflammation ( J:202090 )

• lymphoid infiltration in the interstitial and perivascular space of the kidney at 6 months

digestive/alimentary system

intestinal inflammation ( J:202090 )

• lymphoid infiltration in the intestine at 6 months

stomach inflammation ( J:202090 )

• lymphoid infiltration in the stomach at 6 months

neoplasm

increased acute lymphoblastic leukemia incidence ( J:202090 )

• mice rapidly develop and succumb to acute leukemia

behavior/neurological

lethargy ( J:202090 )

growth/size/body

distended abdomen ( J:202090 )

• in diseased mice

enlarged kidney ( J:202090 )

• in diseased mice

enlarged liver ( J:202090 )

• in diseased mice

enlarged spleen ( J:202090 )

• in diseased mice

respiratory system

respiratory distress ( J:202090 )

liver/biliary system

enlarged liver ( J:202090 )

• in diseased mice

liver inflammation ( J:202090 )

• lymphoid infiltration in the perivascular cuffs in the liver at 6 months

nervous system

meningitis ( J:202090 )

• lymphoid infiltration in the meninges surrounding the brain at 6 months

renal/urinary system

enlarged kidney ( J:202090 )

• in diseased mice

kidney inflammation ( J:202090 )

• lymphoid infiltration in the interstitial and perivascular space of the kidney at 6 months

hematopoietic system

enlarged thymus ( J:202090 )

• in diseased mice

abnormal thymus physiology ( J:202090 )

• lymphoid infiltration in the thymus at 6 months

enlarged spleen ( J:202090 )

• in diseased mice

anemia ( J:202090 )

• slightly at 6 months

thrombocytopenia ( J:202090 )

• severely at 6 months

abnormal leukocyte morphology ( J:202090 )

• monomorphic, enlarged white blood cells with a high nuclear:chromatin ratio (consistent with leukemic blasts) at 6 months

decreased pro-B cell number ( J:202090 )

arrested B cell differentiation ( J:202090 )

• nearly all B cells are arrested in the early pro-B stage

decreased double-positive T cell number ( J:202090 )

• in the thymus

decreased B cell number ( J:202090 )

• in the spleen

decreased mature B cell number ( J:202090 )

decreased pre-B cell number ( J:202090 )

increased leukocyte cell number ( J:202090 )

• at 6 months

increased CD8-positive, alpha-beta T cell number ( J:202090 )

• in the thymus

increased single-positive T cell number ( J:202090 )

• immature single positive cells in the thymus

increased large unstained cell number ( J:202090 )

• large, unstained cells (abnormal blasts) in the peripheral blood at 6 months

intermingled spleen red and white pulp ( J:202090 )

• disrupted separation between white and red pulp by infiltrating lymphoblasts at 6 months

endocrine/exocrine glands

enlarged thymus ( J:202090 )

• in diseased mice

abnormal thymus physiology ( J:202090 )

• lymphoid infiltration in the thymus at 6 months