Phenotypes for Nr2c2 Pax3 MGI:5517372 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Nr2c2^tm1Bbm/Nr2c2^tm1Bbm Pax3^tm1(cre)Joe/Pax3⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr2c2^tm1Bbm mutation (0 available); any Nr2c2 mutation (67 available)
Pax3^tm1(cre)Joe mutation (1 available); any Pax3 mutation (50 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

decreased pruritus ( J:197895 )

• puritogen-induced itch is absent

nervous system

decreased neuron number ( J:197895 )

behavior/neurological

increased chemical nociceptive threshold ( J:197895 )

• in response to formalin

abnormal mechanical nociception ( J:197895 )

• mice exhibit increased reflex withdrawal thresholds in the von Frey test of mechanical pain compared with wild-type mice

increased thermal nociceptive threshold ( J:197895 )

• mice exhibit high response latencies in a hot plate test compared with wild-type mice

• however, mice exhibit normal response in the Hargreaves and tail immersion reflex withdrawal tests

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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