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Phenotypes Associated with This Genotype
Genotype
MGI:5516484
Allelic
Composition
Tgif1tm1.1Caw/Tgif1tm1.1Caw
Genetic
Background
B6.129S-Tgif1tm1.1Caw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgif1tm1.1Caw mutation (0 available); any Tgif1 mutation (28 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer (10.84%) than the expected 25% of mutants are seen at weaning from heterozygous intercrosses
• fewer (27.9%) than the expected 50% of homozygotes are seen at weaning from heterozygous female to homozygous male crossings, indicating embryonic or neonatal lethality

embryo
• central regions of the placental labyrinths are less well developed
• reduction in maternal blood spaces in placentas
• the maternal blood spaces appear larger with fewer surrounding fetal vessels

growth/size/body
• shorter face

hearing/vestibular/ear
• mucus-type ear effusion at 2 months of age, with a high density of goblet cells in the epithelium of the middle ear cavity
• increase in mucosal thickness of the middle ear
• polyps that arise from the middle ear mucosa are seen at 4 months of age
• the average auditory-evoked brainstem response thresholds are elevated by about 30 dB SPL in mutants at 2 months of age, suggesting conductive hearing loss
• 50% of mutants have reduced hearing and 14% have almost normal hearing, although still reduced compared to wild-type mice, at 2 months of age
• however, no abnormalities are seen in the cochlea or organ of Corti and no loss of spinal ganglion neurons is seen
• the average auditory-evoked brainstem response thresholds are elevated by about 30 dB SPL in mutants at 2 months of age, suggesting conductive hearing loss
• 36% of mice are deaf at 2 months of age
• mutants exhibit otitis media by 21 days of age, with 67% of mutants having fluid in the middle ear cavity and a thickened epithelial lining
• inflammation progresses to a chronic inflammation with effusion by 2 months of age
• appearance of cellular debris-like aggregates in the ear effusions at 2 and 4 months of age
• middle ear fluid contains granulocytes, monocytes, and macrophages and the infammatory cell populations vary over time

behavior/neurological
• 86% of mutants show a reduced Preyer's reflex at 1 month of age, and all mutants show reduced hearing by 2 months of age

craniofacial
• shorter face

homeostasis/metabolism
• mutants exhibit ear effusions at P21 that develop into mucus-type effusions at 2 months of age
• levels of cytokines, TNF-alpha and IL-1beta, are elevated in ear fluids

immune system
• middle ear fluid contains granulocytes, monocytes, and macrophages and the infammatory cell populations vary over time
• mutants exhibit otitis media by 21 days of age, with 67% of mutants having fluid in the middle ear cavity and a thickened epithelial lining
• inflammation progresses to a chronic inflammation with effusion by 2 months of age
• appearance of cellular debris-like aggregates in the ear effusions at 2 and 4 months of age
• levels of cytokines, TNF-alpha and IL-1beta, are elevated in ear fluids

nervous system
• 11 of 67 mutants develop hydrocephalus at 11 months of age

skeleton

reproductive system
• by E13.5, the number of resorbed embryos is increased and only 56.25% of embryos appear normal
• only 1 of 5 females gives birth to pups when mated with homozygous males

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
otitis media DOID:10754 OMIM:166760
J:198238


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory