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Phenotypes Associated with This Genotype
Genotype
MGI:5516191
Allelic
Composition
Slc6a2tm1.1Mkh/Slc6a2+
Genetic
Background
B6.129S6-Slc6a2tm1.1Mkh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a2tm1.1Mkh mutation (0 available); any Slc6a2 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• decreased mobility in the tail suspension test
• in an elevated plus maze, mice spend less time in open arms and more time in closed arms, freezing incidence and duration of freezing and fewer head dips than wild-type mice
• in an open field

homeostasis/metabolism
• increased in the urine of male, but not female, mice

cardiovascular system
N
• mice exhibit normal blood pressure and baroreflex sensitivity
• over both a 24 hr period and at night

nervous system
N
• mice exhibit normal baroreflex sensitivity
• increased in the urine of male, but not female, mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
heart conduction disease DOID:10273 J:200046


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory