Phenotypes Associated with This Genotype

Genotype
MGI:5516118

• Allelic Composition: Mmp2^tm1Ito/Mmp2^tm1Ito; Timp3^tm1Osya/Timp3^tm1Osya
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal aorta wall morphology ( J:193744 )

♂ • angiotensin II infused mutants exhibit a greater disruption of the medial elastic lamellae and fibrillar structures in the abdominal aortic walls than in single Timp3 homozygotes

abnormal abdominal aorta morphology ( J:193744 )

♂ • angiotensin II infused mutants exhibit a greater disruption of the medial elastic lamellae and fibrillar structures in the abdominal aortic walls than in single Timp3 homozygotes

increased susceptibility to induced aneurysm formation ( J:193744 )

♂ • 75% of mutants develop abdominal aortic aneurysm with greater than 50% aortic dilation in the suprarenal region after 4 weeks of angiotensin II infusion

♂ • survival is compromised more than in single Timp3 homozygotes after angiotensin II infusion due to aortic rupture, with mice showing around 70% survival 28 days after infusion

♂ • treatment with a broad spectrum protease inhibitor, PD166793, during the course of angiotensin II infusion blocks abdominal aortic aneurysm development

aortitis ( J:193744 )

♂ • mutants treated with angiotensin II exhibit heightened inflammation in the abdominal aorta, with enhanced infiltration of neutrophils and macrophages

immune system

aortitis ( J:193744 )

♂ • mutants treated with angiotensin II exhibit heightened inflammation in the abdominal aorta, with enhanced infiltration of neutrophils and macrophages

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:193744 )

♂ • survival is compromised more than in single Timp3 homozygotes after angiotensin II infusion due to aortic rupture, with mice showing around 70% survival 28 days after infusion