Phenotypes Associated with This Genotype

Genotype
MGI:5515881

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

increased keratinocyte proliferation ( J:197037 )

• at more than 3 months of age in the epidermis

increased skin squamous cell carcinoma incidence ( J:197037 )

• in some mice at 5 to10 months of age

digestive/alimentary system

esophagus hyperplasia ( J:197037 )

• esophageal hyperplasia in all three mice at 1.2 years of age

neoplasm

increased skin squamous cell carcinoma incidence ( J:197037 )

• in some mice at 5 to10 months of age

cellular

increased keratinocyte proliferation ( J:197037 )

• at more than 3 months of age in the epidermis

growth/size/body

esophagus hyperplasia ( J:197037 )

• esophageal hyperplasia in all three mice at 1.2 years of age