Phenotypes Associated with This Genotype

Genotype
MGI:5515765

• Allelic Composition: Dock1^tm2.1Jfco/Dock1^tm2.1Jfco; Tg(MMTV-Erbb2*,-cre)1Mul/0
• Genetic Background: involves: C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

decreased metastatic potential ( J:196659 )

• 5-fold compared with Tg(MMTV-Erbb2*,-cre)1Mul mice

• all lung metastases are confined to the lung vasculature

increased tumor cell death ( J:196659 )

• increased apoptosis in mammary gland tumors

decreased tumor cell proliferation ( J:196659 )

• decreased proliferation in mammary gland tumors

decreased tumor growth/size ( J:196659 )

• fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• decreased proliferation and increased apoptosis in mammary gland tumors

• however, tumor angiogenesis is normal

increased tumor latency ( J:196659 )

• later onset onset than in Tg(MMTV-Erbb2*,-cre)1Mul mice

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors

integument

increased mammary gland tumor incidence ( J:196659 )

• with later onset but fewer large tumors onset and reduced total tumor volume than in Tg(MMTV-Erbb2*,-cre)1Mul mice

• reduced intraepithelial neoplastic lesions

increased mammary adenocarcinoma incidence ( J:196659 )

• solid tumors