Phenotypes Associated with This Genotype

Genotype
MGI:5515726

• Allelic Composition: Mirc14^tm1.1Ankr/Mirc14^tm1.1Ankr
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:196134 )

N • mice exhibit normal thymus cellularity

N • unconventional T cells population such as delta/gamma T cells and intestinal intraepithelial lymphotcytes are essentially unaffected

abnormal T cell differentiation ( J:196134 )

• slight alterations in early T lineage progenitor numbers

• defect in the transition from stage 0 and stage 1 of iNK T cells with fewer stage 1 than stage 0 precursors due to reduced proliferation

• reduced absolute numbers of stage 2 and stage 3 iNK T cells

• however, exogenous ligand rescues iNK T cell development beyond stage 0

decreased double-positive T cell number ( J:196134 )

• in frequency

increased CD4-positive, alpha-beta T cell number ( J:196134 )

• thymocytes

abnormal NK T cell morphology ( J:196134 )

• impaired agonist selection of iNK T cells

decreased NK T cell number ( J:196134 )

• 15-fold reduction in the frequency and reduced absolute numbers of invariant NK T cells in the thymus

• 9-fold of iNK T cells in the spleen

• 11-fold of iNK T cells in the liver

• reduced variant NK T cells in the thymus, spleen and liver

abnormal alpha-beta intraepithelial T cell morphology ( J:196134 )

• mild defect with slight alterations in early T lineage progenitor numbers

decreased interferon-gamma secretion ( J:196134 )

• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes

decreased interleukin-13 secretion ( J:196134 )

• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes

decreased interleukin-4 secretion ( J:196134 )

• from splenic iNK T cells stimulated with alphaGalCer-loaded splenocytes

hematopoietic system

abnormal T cell differentiation ( J:196134 )

• slight alterations in early T lineage progenitor numbers

• defect in the transition from stage 0 and stage 1 of iNK T cells with fewer stage 1 than stage 0 precursors due to reduced proliferation

• reduced absolute numbers of stage 2 and stage 3 iNK T cells

• however, exogenous ligand rescues iNK T cell development beyond stage 0

decreased double-positive T cell number ( J:196134 )

• in frequency

increased CD4-positive, alpha-beta T cell number ( J:196134 )

• thymocytes

abnormal NK T cell morphology ( J:196134 )

• impaired agonist selection of iNK T cells

decreased NK T cell number ( J:196134 )

• 15-fold reduction in the frequency and reduced absolute numbers of invariant NK T cells in the thymus

• 9-fold of iNK T cells in the spleen

• 11-fold of iNK T cells in the liver

• reduced variant NK T cells in the thymus, spleen and liver

abnormal alpha-beta intraepithelial T cell morphology ( J:196134 )

• mild defect with slight alterations in early T lineage progenitor numbers