Phenotypes Associated with This Genotype

Genotype
MGI:5515635

• Allelic Composition: Pax5^tm1Mbu/Pax5^tm1Mbu
• Genetic Background: either: 129 or (involves: 129S2/SvPas * C57BL/6J)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal lymphopoiesis ( J:21935 )

• no pre-B cell lines can be obtained from Pax5-deficient livers while they are readily established from livers of fetal heterozygous and wild-type livers

• fetal liver cannot support development of early B-lymphoid progenitors

• when fetal liver cells from mutants are transplanted into lethally irradiated hosts however, pre-B cell precursors can be detected in bone marrow of hosts

abnormal late pro-B cell ( J:21935 )

• incidence of V to DJ rearrangement of the immunoglobulin heavy chain is reduced 10-fold in Pax5-deficient mice

absent late pro-B cells ( J:21935 )

• development is halted at early pro-B cell stage

arrested B cell differentiation ( J:21935 )

• B cell development is arrested at the early pro-B stage in bone marrow

immune system

abnormal lymphopoiesis ( J:21935 )

• no pre-B cell lines can be obtained from Pax5-deficient livers while they are readily established from livers of fetal heterozygous and wild-type livers

• fetal liver cannot support development of early B-lymphoid progenitors

• when fetal liver cells from mutants are transplanted into lethally irradiated hosts however, pre-B cell precursors can be detected in bone marrow of hosts

abnormal late pro-B cell ( J:21935 )

• incidence of V to DJ rearrangement of the immunoglobulin heavy chain is reduced 10-fold in Pax5-deficient mice

absent late pro-B cells ( J:21935 )

• development is halted at early pro-B cell stage

arrested B cell differentiation ( J:21935 )

• B cell development is arrested at the early pro-B stage in bone marrow