Phenotypes Associated with This Genotype

Genotype
MGI:5515397

• Allelic Composition: Hdac3^tm1.1Laz/Hdac3^tm1.1Laz; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:199860 )

• no viable adults are obtained; mice are born at the expected Mendelian ratio, but none survive beyond 25 days of age

postnatal lethality, incomplete penetrance ( J:199860 )

• more than 50% die before postnatal day 5 (P5); remaining animals display failure to thrive and a wasting phenotype

growth/size/body

cachexia ( J:199860 )

• animals surviving past P5 fail to thrive and display a wasting phenotype