Phenotypes Associated with This Genotype

Genotype
MGI:5515216

• Allelic Composition: Sgpl1^tm1.2Npa/Sgpl1^tm1.2Npa
• Genetic Background: involves: BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:199525 )

• animals die within 3 or 4 weeks of birth

growth/size/body

abnormal postnatal growth ( J:199525 )

• mice do not gain weight after birth

hematopoietic system

spleen hypoplasia ( J:199525 )

immune system

spleen hypoplasia ( J:199525 )

homeostasis/metabolism

abnormal lipid homeostasis ( J:199525 )

• 2 weeks after birth, levels of S1P (Sgpl1 substrate) are elevated (120-fold in lung to 4700-fold in thymus) with no significant increase in the brain or spinal cord

• ceramide (S1P precursor) is elevated 9-fold with Sph (S1P precursor) increased up to 200-fold