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Phenotypes Associated with This Genotype
Genotype
MGI:5514500
Allelic
Composition		 Rad50tm2.1Flv/Rad50tm2.1Flv
Genetic
Background		 B6.129S6-Rad50tm2.1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm2.1Flv mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased interleukin-13 secretion ( J:196154 )
• from CD4+ T cells cultured under in vitro Th2-polarizing conditions with anti-CD3 antibodies
• from splenocytes of mice stimulated with ovalbumin and restimulated in vitro with ovalbumin
• from skin draining lymph nodes of mice subjected to epicutaneous priming followed by restimulation with ovalbumin in the presence of splenic antibody presenting cells
decreased interleukin-4 secretion ( J:196154 )
• from CD4+ T cells cultured under in vitro Th2-polarizing conditions with anti-CD3 antibodies
decreased interleukin-5 secretion ( J:196154 )
• from CD4+ T cells cultured under in vitro Th2-polarizing conditions with anti-CD3 antibodies
• from splenocytes of mice stimulated with ovalbumin and restimulated in vitro with ovalbumin

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory