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Phenotypes Associated with This Genotype
Genotype
MGI:5514419
Allelic
Composition		 Gfra1tm2Jmi/Gfra1tm3Jmi
Tg(Hoxb7-cre)13Amc/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gfra1tm2Jmi mutation (0 available); any Gfra1 mutation (33 available)
Gfra1tm3Jmi mutation (0 available); any Gfra1 mutation (33 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
absent kidney ( J:199323 )
• at P0, most have bilateral kidney agenesis/aplasia (16/20)
single kidney ( J:199323 )
• at P0, a few pups (3/20) have unilateral kidney agenesis and contralateral megaureter
large ureter ( J:199323 )
• at P0, a few pups (3/20) have unilateral kidney agenesis and contralateral megaureter

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory