Phenotypes Associated with This Genotype

Genotype
MGI:5514365

• Allelic Composition: Cd70^tm1(cre)Jbo/Cd70^tm1(cre)Jbo
• Genetic Background: B6.129P2-Cd70^tm1(cre)Jbo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased regulatory T cell number ( J:198200 )

• frequency and absolute number of CD4+ve Foxp3+ve T (Treg) cells is reduced in adult mice

• frequency and absolute number of CD4+ve Foxp3+ve T cells in thymi of neonates is reduced compared to WT

• treatment with neutralizing antibodies to CD80/CD86 drastically reduces number of Treg cells in the thymus; CD28 signaling blockade reduces number of thymic pre-Treg (CD4+Foxp3-CD25+) cells

immune system

immune system phenotype ( J:198200 )

N • CD4+ve Foxp3-ve T cell (pre-Treg) numbers in thymus and spleen are comparable to controls; immature thymocyte populations and CD4-ve CD8+ve populations in thymus and spleen are similar to contols

decreased regulatory T cell number ( J:198200 )

• frequency and absolute number of CD4+ve Foxp3+ve T (Treg) cells is reduced in adult mice

• frequency and absolute number of CD4+ve Foxp3+ve T cells in thymi of neonates is reduced compared to WT

• treatment with neutralizing antibodies to CD80/CD86 drastically reduces number of Treg cells in the thymus; CD28 signaling blockade reduces number of thymic pre-Treg (CD4+Foxp3-CD25+) cells