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Phenotypes Associated with This Genotype
Genotype
MGI:5514270
Allelic
Composition		 Mdwh/Mdwh
Pou1f1dw/Pou1f1dw
Genetic
Background		 involves: CAST/EiJ * DW/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mdwh mutation (0 available); any Mdwh mutation (0 available)
Pou1f1dw mutation (2 available); any Pou1f1 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
decreased threshold for auditory brainstem response ( J:177740 )
• ABR thresholds for click responses are 72.8 db as compared to 84.8 db for Mdwh heterozygotes and 97.8 for homozygous Mdwh+ controls
• ABR thresholds for 8 kHz signals are 72.4 db as compared to 81.6 db for Mdwh heterozygotes and 95.9 db for homozygous Mdwh+ controls
• ABR thresholds for 16 kHz signals are 51.6 db as compared to 64.3 db for Mdwh heterozygotes and 84.3 db for homozygous Mdwh+ controls
• ABR thresholds for 32 kHz signals are 75.2 db as compared to 87.1 db for Mdwh heterozygotes and 97.9 db for homozygous Mdwh+ controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory