Phenotypes for Mterf1a Mterf1b MGI:5514268 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Mterf1a^tm1.2Lrsn/Mterf1a^tm1.2Lrsn Mterf1b^tm1Lrsn/Mterf1b^tm1Lrsn
Genetic Background	B6N.Cg-Mterf1a^tm1.2Lrsn Mterf1b^tm1Lrsn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mterf1a^tm1.2Lrsn mutation (0 available); any Mterf1a mutation (21 available)
Mterf1b^tm1Lrsn mutation (0 available); any Mterf1b mutation (13 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell physiology ( J:198969 )

• mice exhibit impaired transcription initiation at light-strand promoters resulting in a decrease of de novo transcription and reduced 7S RNA compared with wild-type mice

• however, mice exhibit normal oxidative phosphorylation capacity and maintenance and replication of mitochondrial DNA, and biogenesis of mitochondrial rRNAs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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