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Phenotypes Associated with This Genotype
Genotype
MGI:5514245
Allelic
Composition		 Tgfbr2tm1.2Hlm/Tgfbr2tm1.2Hlm
Tnfrsf4tm2(cre)Nik/Tnfrsf4+
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
Genetic
Background		 involves: 129 * C57BL/6 * NOD * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfbr2tm1.2Hlm mutation (0 available); any Tgfbr2 mutation (38 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation (3 available)
Tnfrsf4tm2(cre)Nik mutation (1 available); any Tnfrsf4 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:196160 )
N
• absolute number of T reg cells in the spleen and the pancreatic lymph nodes are normal
increased susceptibility to autoimmune diabetes ( J:196160 )
• development of diabetes is somewhat delayed

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory