Phenotypes Associated with This Genotype

Genotype
MGI:5514241

• Allelic Composition: Tgfbr2^tm1.2Hlm/Tgfbr2^tm1.2Hlm; Tg(Cd4-cre)1Cwi/0; Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:196160 )

N • improved survival

immune system

immune system phenotype ( J:196160 )

N • absolute numbers of Th1 cells in the spleen is unchanged from controls

abnormal immune system morphology ( J:196160 )

decreased regulatory T cell number ( J:196160 )

• significant reduction in spleen and pancreas

• reduced peripheral cell numbers

increased regulatory T cell number ( J:196160 )

• percentage in pancreatic lymph nodes is increased

abnormal immune system organ morphology ( J:196160 )

abnormal spleen morphology ( J:196160 )

• total cellularity of the spleen is reduced in 3 week old diabetic mice

abnormal abdominal lymph node morphology ( J:196160 )

• total cellularity of pancreatic lymph nodes is reduced in 3 week old diabetic mice

abnormal immune system physiology ( J:196160 )

pancreas inflammation ( J:196160 )

• massive infiltration of leukocytes into Islets before diabetes develops

abnormal immune serum protein physiology ( J:196160 )

increased interferon-gamma secretion ( J:196160 )

• in pancreatic T cells

abnormal interleukin secretion ( J:196160 )

• decreased Il22 expression in pancreatic T cells

decreased interleukin-17 secretion ( J:196160 )

• decreased Il17a in pancreatic T cells

increased interleukin-2 secretion ( J:196160 )

• in pancreatic T cells

increased interleukin-21 secretion ( J:196160 )

• in pancreatic T cells

decreased interleukin-9 secretion ( J:196160 )

• in pancreatic T cells

increased susceptibility to autoimmune diabetes ( J:196160 )

• become diabetic between 14 and 21 days of age

endocrine/exocrine glands

pancreas inflammation ( J:196160 )

• massive infiltration of leukocytes into Islets before diabetes develops

hematopoietic system

decreased regulatory T cell number ( J:196160 )

• significant reduction in spleen and pancreas

• reduced peripheral cell numbers

increased regulatory T cell number ( J:196160 )

• percentage in pancreatic lymph nodes is increased

abnormal spleen morphology ( J:196160 )

• total cellularity of the spleen is reduced in 3 week old diabetic mice