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Phenotypes Associated with This Genotype
Genotype
MGI:5514239
Allelic
Composition		 Tgfb1tm3.1Flv/Tgfb1tm3.1Flv
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2 * NOD
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation (12 available)
Tgfb1tm3.1Flv mutation (0 available); any Tgfb1 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• expansion of thymic and peripheral T reg cells

hematopoietic system
increased T-helper 1 cell number ( J:196160 )
• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
increased regulatory T cell number ( J:196160 )
• expansion of thymic and peripheral T reg cells

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory