Phenotypes Associated with This Genotype

Genotype
MGI:5514237

• Allelic Composition: Tgfb1^tm3.1Flv/Tgfb1^tm3.1Flv; Tg(Cd4-cre)1Cwi/0; Tg(TcraBDC2.5,TcrbBDC2.5)1Doi/0
• Genetic Background: involves: 129 * C57BL/6 * DBA/2 * NOD * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased T-helper 1 cell number ( J:196160 )

• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes

increased regulatory T cell number ( J:196160 )

• increased frequency of T reg in the thymus and pancreatic lymph nodes

• number of T reg cells in pancreatic lymph nodes is increased as well

increased susceptibility to autoimmune diabetes ( J:196160 )

• rapidly develop diabetes but with a low incidence

• slow kinetics of disease progression

hematopoietic system

increased T-helper 1 cell number ( J:196160 )

• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes

increased regulatory T cell number ( J:196160 )

• increased frequency of T reg in the thymus and pancreatic lymph nodes

• number of T reg cells in pancreatic lymph nodes is increased as well