Phenotypes Associated with This Genotype

Genotype
MGI:5512646

• Allelic Composition: Tbl1xr1^tm1.1Arte/Tbl1xr1^tm1.1Arte; Tg(Fabp4-cre)1Rev/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:198124 )

• in mice fed a high fat diet

increased circulating leptin level ( J:198124 )

• in mice fed a high fat diet

impaired glucose tolerance ( J:198124 )

• whether mice are fed standard chow or a high fat diet

insulin resistance ( J:198124 )

• whether mice are fed standard chow or a high fat diet

increased liver triglyceride level ( J:198124 )

• in mice fed a high fat diet, but not standard chow

increased skeletal muscle triglyceride level ( J:198124 )

• increased in muscle whether mice are fed standard chow or a high fat diet

impaired lipolysis ( J:198124 )

• in mice fed a high fat diet

muscle

increased skeletal muscle triglyceride level ( J:198124 )

• increased in muscle whether mice are fed standard chow or a high fat diet

adipose tissue

increased total body fat amount ( J:198124 )

• at 14 weeks when fed standard chow

• in mice fed a high fat diet

increased inguinal fat pad weight ( J:198124 )

• in mice fed a high fat diet

increased abdominal fat pad weight ( J:198124 )

• in mice fed a high fat diet

abnormal white adipose tissue morphology ( J:198124 )

• crown-like structures indicating increased damage in mice fed a high fat diet

• impaired fasting-induced fat pad weight reduction

increased white fat cell number ( J:198124 )

• in mice fed a high fat diet, but not standard chow

increased white fat cell size ( J:198124 )

• whether mice are fed standard chow or a high fat diet

abnormal adipose tissue physiology ( J:198124 )

• impaired release of NEFA and glycerol in abdominal white and brown adipose tissue explants in response to beta-adrenoceptor agonist treatment

growth/size/body

increased body weight ( J:198124 )

• at 14 weeks when fed standard chow

• in mice fed a high fat diet

increased susceptibility to diet-induced obesity ( J:198124 )

• in mice fed a high fat diet

liver/biliary system

increased liver triglyceride level ( J:198124 )

• in mice fed a high fat diet, but not standard chow