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Phenotypes Associated with This Genotype
Genotype
MGI:5511133
Allelic
Composition		 Siglechtm1.1Cln/Siglech+
Tg(CLEC4C-HBEGF)956Cln/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Siglechtm1.1Cln mutation (0 available); any Siglech mutation (23 available)
Tg(CLEC4C-HBEGF)956Cln mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased plasmacytoid dendritic cell number ( J:166504 )
• diptheria toxin administration induces selective depletion of plasmacytoid dendritic cells (pDC), but does not reduce numbers of classical DC

immune system
decreased plasmacytoid dendritic cell number ( J:166504 )
• diptheria toxin administration induces selective depletion of plasmacytoid dendritic cells (pDC), but does not reduce numbers of classical DC

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory