Mouse Genome Informatics
tg
    Tg(ACTB-Eif4e)#Ppp/?
B6.Cg-Tg(ACTB-Eif4e)#Ppp
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
behavior/neurological
• mutants exhibit increased self grooming (J:194400)
• although learning ability in the acquisition and memory phases of the water-based Y maze and modified Morris water maze tasks are intact, males are impaired in locating the new platform positions in the reversal phases (J:194400)
• males exhibit mild hyperactivity, however no impairments in motor coordination, motor learning and sensorimotor gating (J:194400)
• males exhibit repetitive digging behavior in the marble-burying test (J:194400)
• males do not show a preference for a nonspecific stranger versus a new, inanimate object (J:194400)
• males exhibit diminished reciprocal interactions with a freely moving stranger mouse (J:194400)
• treatment with 4DGI-1, an inhibitor of Eif4e-Eif4g interactions, results in a decrease in repetitive behaviors, perseverative behaviors, and in social behavior deficits (J:194400)

nervous system
• about 12% increase in spine density and smaller spine volume in layer 2/3 medial prefrontal cortex pyramidal neurons
• mutants exhibit an increase in the frequency, but not amplitude, of miniature excitatory postsynaptic currents in layers 2/3 of acute medial prefrontal cortex slices
• mutants exhibit an increase in the amplitude, but not frequency, of miniature inhibitory postsynaptic currents in layers 2/3 of acute medial prefrontal cortex slices
• mutants exhibit enhanced long-term depression in the striatum
• mutants exhibit enhanced hippocampal metabotropic glutamate receptor dependent (mGluR)-long-term depression
• treatment with 4DGI-1, an inhibitor of Eif4e-Eif4g interactions, normalizes the enhanced striatal long term depression

Mouse Models of Human Disease
OMIM IDRef(s)
Autism 209850 J:194400