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Phenotypes Associated with This Genotype
Genotype
MGI:5510994
Allelic
Composition
Tg(ACTB-Eif4e)#Ppp/?
Genetic
Background
B6.Cg-Tg(ACTB-Eif4e)#Ppp
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phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• although learning ability in the acquisition and memory phases of the water-based Y maze and modified Morris water maze tasks are intact, males are impaired in locating the new platform positions in the reversal phases
• mutants exhibit increased self grooming
• males exhibit mild hyperactivity, however no impairments in motor coordination, motor learning and sensorimotor gating
• males exhibit repetitive digging behavior in the marble-burying test
• males do not show a preference for a nonspecific stranger versus a new, inanimate object
• males exhibit diminished reciprocal interactions with a freely moving stranger mouse
• treatment with 4DGI-1, an inhibitor of Eif4e-Eif4g interactions, results in a decrease in repetitive behaviors, perseverative behaviors, and in social behavior deficits

nervous system
• about 12% increase in spine density and smaller spine volume in layer 2/3 medial prefrontal cortex pyramidal neurons
• mutants exhibit an increase in the frequency, but not amplitude, of miniature excitatory postsynaptic currents in layers 2/3 of acute medial prefrontal cortex slices
• mutants exhibit an increase in the amplitude, but not frequency, of miniature inhibitory postsynaptic currents in layers 2/3 of acute medial prefrontal cortex slices
• mutants exhibit enhanced long-term depression in the striatum
• mutants exhibit enhanced hippocampal metabotropic glutamate receptor dependent (mGluR)-long-term depression
• treatment with 4DGI-1, an inhibitor of Eif4e-Eif4g interactions, normalizes the enhanced striatal long term depression

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:194400


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory