Phenotypes Associated with This Genotype

Genotype
MGI:5510987

• Allelic Composition: Tg(ACTB-Eif4e)#Ppp/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:89878 )

• mutants exhibit an increase in tumorigenesis beginning at 16 months of age

increased liver adenoma incidence ( J:89878 )

• 21% of tumors are hepatocellular adenomas

increased B cell derived lymphoma incidence ( J:89878 )

• 16% of tumors are B-cell lymphomas

increased lung adenocarcinoma incidence ( J:89878 )

• 21% of tumors are lung adenocarcinomas

increased sarcoma incidence ( J:89878 )

• 13% of tumors are angiosarcomas

cellular

early cellular replicative senescence ( J:89878 )

• mutants exhibit an increase in senescence-associated beta-galactosidase staining of splenic B cells, indicating increased senescence of splenic B cells at 3 weeks of age

liver/biliary system

increased liver adenoma incidence ( J:89878 )

• 21% of tumors are hepatocellular adenomas

respiratory system

increased lung adenocarcinoma incidence ( J:89878 )

• 21% of tumors are lung adenocarcinomas