Phenotypes Associated with This Genotype

Genotype
MGI:5510822

• Allelic Composition: Crkl^snoopy/Crkl^snoopy
• Genetic Background: involves: C3H/HeH * C57BL/6JAnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Craniofacial and skeletal mutants: (A-D) Fras1^bfb, (E-G) Ift140^cauli, (H-J) knyn, and (K-M) Crkl^snoopy homozygotes

vision/eye

abnormal eye development ( J:199856 )

• poorly developed at E13.5

cyclopia ( J:199856 )

• in some mice

ocular hypotelorism ( J:199856 )

• at E13.5

craniofacial

absent mandible ( J:199856 )

• hypoplasia/aplasia at E13.5

mandible hypoplasia ( J:199856 )

• hypoplasia/aplasia at E13.5

nervous system

holoprosencephaly ( J:199856 )

• some mice exhibit complete failure of forebrain vesicle separation

abnormal forebrain morphology ( J:199856 )

• at E13.5

skeleton

absent mandible ( J:199856 )

• hypoplasia/aplasia at E13.5

mandible hypoplasia ( J:199856 )

• hypoplasia/aplasia at E13.5