Phenotypes Associated with This Genotype

Genotype
MGI:5509191

• Allelic Composition: Arpc3^tm1Ssod/Arpc3^tm1Ssod; Tg(Camk2a-cre)T29-1Stl/0
• Genetic Background: involves: 129S6/SvEvTac * BALB/c * C57BL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196577 )

N • mice exhibit normal basal startle responses

abnormal object recognition memory ( J:196577 )

• in a novel object recognition test, adolescent and adult mice exhibit disrupted episodic learning and memory compared with control mice

• early and pronounced deficit in short-term, long-term and remote memory in a novel object recognition test

impaired long-term object recognition memory ( J:196577 )

• impaired in adolescent and adult mice in a novel object recognition test

impaired short-term object recognition memory ( J:196577 )

• impaired in adolescent and adult mice in a novel object recognition test

abnormal spatial working memory ( J:196577 )

• impaired in adult, but not adolescent, mice in a Y-maze

hyperactivity ( J:196577 )

• adult, but not adolescent, mice in the home cage

increased vertical activity ( J:196577 )

• in adult, but not adolescent, mice

increased stereotypic behavior ( J:196577 )

• in adult, but not adolescent, mice

abnormal social/conspecific interaction behavior ( J:196577 )

• reduced social interaction of in adult, but not adolescent, mice

nervous system

abnormal dendritic spine morphology ( J:196577 )

• progressive loss of spine at P120

• neurons exhibit a decreased fraction of mushroom type spines and increased filopodia-like spines compared with control neurons

abnormal synapse morphology ( J:196577 )

• at 4 months, mice exhibit a loss of synapses onto spines in the stratum radiatum of the hippocampus and cerebral cortex compared with control mice

decreased prepulse inhibition ( J:196577 )

• in adolescent and adult mice