Phenotypes Associated with This Genotype

Genotype
MGI:5509049

• Allelic Composition: Rc3h1^san/Rc3h1^san; Rc3h2^tm1.2Cgv/Rc3h2^tm1.2Cgv
• Genetic Background: involves: C57BL/6 * C57BL/6JSfdAnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:196137 )

• premature and fully penetrant mortality before 22 weeks of age

immune system

increased T follicular helper cell number ( J:196137 )

• elevated percentage of Tfh cells

increased circulating tumor necrosis factor level ( J:196137 )

• 100 fold increase in TNF levels in mice surviving low doses of LPS

increased inflammatory response ( J:196137 )

• more sever inflammatory infiltrates of many organs

kidney inflammation ( J:196137 )

• more sever inflammatory infiltrates

increased susceptibility to bacterial infection ( J:196137 )

• increased susceptibility to low doses of lipopolysaccharide

• three of four died of low doses which are not lethal to mice homozygous for a single mutation

hematopoietic system

increased T follicular helper cell number ( J:196137 )

• elevated percentage of Tfh cells

renal/urinary system

kidney inflammation ( J:196137 )

• more sever inflammatory infiltrates

homeostasis/metabolism

increased circulating tumor necrosis factor level ( J:196137 )

• 100 fold increase in TNF levels in mice surviving low doses of LPS