Mouse Genome Informatics
hm
    Ins2Akita/Ins2Akita
C.B6N-Ins2Akita
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
mortality/aging
• approximately 20% of mutants fail to thrive and are sacrificed at 6 months of age

cardiovascular system
• mice show a decrease in CD31 positive structures in the glomeruli, indicating collapse of the glomerular tufts

growth/size
• reduced body weight at 4 and 6 months of age

homeostasis/metabolism
• 3-fold increase in albumin-to-creatine ratio at 4 months of age; albuminuria persists in mutants at 6 months of age

renal/urinary system
• 3-fold increase in albumin-to-creatine ratio at 4 months of age; albuminuria persists in mutants at 6 months of age
• increase in glomerular collagen IV deposition at 6 months of age
• mice show a decrease in CD31 positive structures in the glomeruli, indicating collapse of the glomerular tufts
• mesangial matrix expansion is seen at 4 months of age and is more pronounced than in heterozygous mice
• same degree of glomerular injury as in heterozygotes at 6 months of age
• small increase in collagen I in the tubulointerstitial compartment of the kidney
• however, tubulointerstitial fibrosis is not observed
• glomerular filtration rate is increased at 4 months of age but decreased by 6 months of age to normal levels

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:198186