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Phenotypes Associated with This Genotype
Genotype
MGI:5508894
Allelic
Composition
Ins2Akita/Ins2Akita
Genetic
Background
C.B6N-Ins2Akita
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ins2Akita mutation (13 available); any Ins2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• approximately 20% of mutants fail to thrive and are sacrificed at 6 months of age

cardiovascular system
• mice show a decrease in CD31 positive structures in the glomeruli, indicating collapse of the glomerular tufts

growth/size/body
• reduced body weight at 4 and 6 months of age

homeostasis/metabolism
• 3-fold increase in albumin-to-creatine ratio at 4 months of age; albuminuria persists in mutants at 6 months of age

renal/urinary system
• 3-fold increase in albumin-to-creatine ratio at 4 months of age; albuminuria persists in mutants at 6 months of age
• increase in glomerular collagen IV deposition at 6 months of age
• mice show a decrease in CD31 positive structures in the glomeruli, indicating collapse of the glomerular tufts
• mesangial matrix expansion is seen at 4 months of age and is more pronounced than in heterozygous mice
• same degree of glomerular injury as in heterozygotes at 6 months of age
• small increase in collagen I in the tubulointerstitial compartment of the kidney
• however, tubulointerstitial fibrosis is not observed
• glomerular filtration rate is increased at 4 months of age but decreased by 6 months of age to normal levels

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:198186


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory