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Phenotypes Associated with This Genotype
Genotype
MGI:5508337
Allelic
Composition		 Krastm1Bbd/Kras+
Raf1tm2Bacc/Raf1tm2Bacc
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Bbd mutation (2 available); any Kras mutation (88 available)
Raf1tm2Bacc mutation (2 available); any Raf1 mutation (116 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:172200 )
• following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre), mice show 50% survival at 63 weeks compared to 38 weeks in single Kras heterozygous controls, indicating an 83% increase in survival

neoplasm
decreased classified tumor incidence ( J:172200 )
• tumor burden is reduced compared to single Kras heterozygotes; tumors that are found express Raf1

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory