Phenotypes Associated with This Genotype

Genotype
MGI:5508243

• Allelic Composition: Kras^tm1Bbd/Kras⁺; Map2k2^tm1Chrn/Map2k2^tm1Chrn
• Genetic Background: involves: 129/Sv * 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:172200 )

• Ad-Cre treated mutants show 50% survival at 52 weeks compared to 45 weeks in single Kras heterozygous controls, indicating a slight 19% increase in survival

neoplasm

increased lung non-small cell carcinoma incidence ( J:172200 )

• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre); tumor burden in similar to that seen in single Kras heterozygotes

respiratory system

increased lung non-small cell carcinoma incidence ( J:172200 )

• mice develop non-small cell lung carcinoma following intratracheal instillation of adenovirus expressing Cre-recombinase (Ad-Cre); tumor burden in similar to that seen in single Kras heterozygotes