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Phenotypes Associated with This Genotype
Genotype
MGI:5506798
Allelic
Composition
Tg(MMTV-rtTA)1Lach/0
Tg(TetO-Erbb2)1Lach/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• mice treated with doxycycline for 21 days develop invasive mammary carcinomas
• chronic treatment with doxycycline results in rapid development of multiple mammary tumors with 100% penetrance and a latency of 6 weeks
• mammary tumors are invasive solid nodular carcinomas
• withdrawal of doxycycline from chronically induced mutants results in full regression of tumors to a nonpalpable state in 94% of mice; a decrease in cell proliferation and increase in cell apoptosis is seen during regression
• mice in which doxycycline withdrawal leads to complete regression of tumors show tumor recurrence in the absence of doxycycline after an average of 153 +/- 93 days off doxycycline
• some mutants treated with doxycycline develop pulmonary metastases (solid pulmonary nodules on the pleural surface); these mice show hunched posture, ruffled fur, labored breathing and die within one week
• pulmonary metastases have features of mammary epithelial carcinomas
• withdrawal of doxycycline from chronically induced mutants with pulmonary metastasis results in regression of primary mammary tumors and resolution of the respiratory phenotype

mortality/aging
• mice that develop pulmonary metastases following chronic doxycycline treatment die within one week of developing a hunched posture and labored breathing

endocrine/exocrine glands
• mice treated with doxycycline for 4 days exhibit hyperplastic abnormalities in the mammary ductal trees
• mice treated with doxycycline for 21 days develop invasive mammary carcinomas
• chronic treatment with doxycycline results in rapid development of multiple mammary tumors with 100% penetrance and a latency of 6 weeks
• mammary tumors are invasive solid nodular carcinomas
• withdrawal of doxycycline from chronically induced mutants results in full regression of tumors to a nonpalpable state in 94% of mice; a decrease in cell proliferation and increase in cell apoptosis is seen during regression
• mice in which doxycycline withdrawal leads to complete regression of tumors show tumor recurrence in the absence of doxycycline after an average of 153 +/- 93 days off doxycycline

integument
• mice treated with doxycycline for 4 days exhibit hyperplastic abnormalities in the mammary ductal trees
• mice treated with doxycycline for 21 days develop invasive mammary carcinomas
• chronic treatment with doxycycline results in rapid development of multiple mammary tumors with 100% penetrance and a latency of 6 weeks
• mammary tumors are invasive solid nodular carcinomas
• withdrawal of doxycycline from chronically induced mutants results in full regression of tumors to a nonpalpable state in 94% of mice; a decrease in cell proliferation and increase in cell apoptosis is seen during regression
• mice in which doxycycline withdrawal leads to complete regression of tumors show tumor recurrence in the absence of doxycycline after an average of 153 +/- 93 days off doxycycline

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:81083


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory