Mouse Genome Informatics
cx
    Tg(MMTV-rtTA)1Lach/0
Tg(TetO-Erbb2)1Lach/0

involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
tumorigenesis
• some mutants treated with doxycycline develop pulmonary metastases (solid pulmonary nodules on the pleural surface); these mice show hunched posture, ruffled fur, labored breathing and die within one week
• pulmonary metastases have features of mammary epithelial carcinomas
• withdrawal of doxycycline from chronically induced mutants with pulmonary metastasis results in regression of primary mammary tumors and resolution of the respiratory phenotype
• mice treated with doxycycline for 21 days develop invasive mammary carcinomas
• chronic treatment with doxycycline results in rapid development of multiple mammary tumors with 100% penetrance and a latency of 6 weeks
• mammary tumors are invasive solid nodular carcinomas
• withdrawal of doxycycline from chronically induced mutants results in full regression of tumors to a nonpalpable state in 94% of mice; a decrease in cell proliferation and increase in cell apoptosis is seen during regression
• mice in which doxycycline withdrawal leads to complete regression of tumors show tumor recurrence in the absence of doxycycline after an average of 153 +/- 93 days off doxycycline

mortality/aging
• mice that develop pulmonary metastases following chronic doxycycline treatment die within one week of developing a hunched posture and labored breathing

endocrine/exocrine glands
• mice treated with doxycycline for 4 days exhibit hyperplastic abnormalities in the mammary ductal trees

integument
• mice treated with doxycycline for 4 days exhibit hyperplastic abnormalities in the mammary ductal trees

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:81083