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Phenotypes Associated with This Genotype
Genotype
MGI:5502748
Allelic
Composition		 Eif4ebp1tm1Nso/Eif4ebp1tm1Nso
Rhebtm1.1Otsu/Rhebtm1.1Otsu
Tg(Myh6-cre)2182Mds/0
Genetic
Background		 involves: 129 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif4ebp1tm1Nso mutation (2 available); any Eif4ebp1 mutation (32 available)
Rhebtm1.1Otsu mutation (0 available); any Rheb mutation (25 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, incomplete penetrance ( J:197831 )
• improved survival compared to in Rhebtm1.1Otsu/Rhebtm1.1Otsu Tg(Myh6-cre)2182Mds mice

cardiovascular system
cardiovascular system phenotype ( J:197831 )
N
• mice exhibit improved cardiac function, hypertrophic growth and sarcomere maturation compared with Rhebtm1.1Otsu/Rhebtm1.1Otsu Tg(Myh6-cre)2182Mds mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory