Phenotypes Associated with This Genotype

Genotype
MGI:5502747

• Allelic Composition: Rheb^tm1.1Otsu/Rheb^tm1.1Otsu; Tg(Myh6-cre)2182Mds/0
• Genetic Background: involves: 129 * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Sarcomere maturation is attenuated in Rheb^tm1.1Otsu/Rheb^tm1.1Otsu Tg(Myh6-cre)2182Mds/0 hearts

mortality/aging

postnatal lethality, complete penetrance ( J:197831 )

• mice die between P8 and P10

cardiovascular system

decreased myocardial fiber size ( J:197831 )

• at P8

thin interventricular septum ( J:197831 )

decreased heart weight ( J:197831 )

• at P8

abnormal heart left ventricle morphology ( J:197831 )

• reduced diastolic left ventricle posterior wall thickness

• larger end-diastolic and systolic dimensions

decreased cardiac muscle contractility ( J:197831 )

• reduced fractional shortening at P8

• however, cardiac function is normal until P5

cardiomyopathy ( J:197831 )

• without the involvement of autophagy

muscle

decreased myocardial fiber size ( J:197831 )

• at P8

decreased cardiac muscle contractility ( J:197831 )

• reduced fractional shortening at P8

• however, cardiac function is normal until P5

cardiomyopathy ( J:197831 )

• without the involvement of autophagy

abnormal sarcomere morphology ( J:197831 )

• sarcomere maturation is attenuated