Mouse Genome Informatics
cn
    Artm1Verh/Y
Tg(Fabp4-cre)1Rev/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue
• while males on a normal chow diet are not obese, they show reduced perigonadal fat weight but increased interscapular brown adipose tissue at 3 months age
• however, body fat composition is no longer different by 6 months of age
• on a high-fat diet, males gain equal weight compared with controls, however after 24 weeks, they have more visceral fat, with increases in omental and mesenteric fat pad weights
• on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age
• however, white adipose tissue morphology in the perigonadal and subcutaneous depots are normal
• on a normal chow diet, males have reduced perigonadal fat weight and proportion
• after 24 weeks of a high-fat diet, males show an increase in mesenteric fat pad weight compared to controls
• after 24 weeks of a high-fat diet, males show an increase in omental fat pad weight compared to controls
• on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age

growth/size/body
• on a normal chow diet, males gain less weight than controls at 3 months of age

homeostasis/metabolism
• males are euglycemic at 3 months of age, however between 3 and 12 months of age, males are unable to sustain the normal increase in insulin secretory capacity, and they develop hyperglycemia
• after 24 weeks on a high-fat diet, mutants have a poorer secretory response and become more hyperglycemic than controls
• males are euglycemic but hyperinsulinemic both in the fasted state and during glucose tolerance testing at 3 months of age
• 3 month old males have elevated plasma triglyceride levels but normal liver triglycerides
• males show age-related glucose intolerance
• insulin resistance in 3 month old males on a normal diet, as indicated by hyperinsulinemia both in the fasted state and during glucose tolerance

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:196857