Mouse Genome Informatics
cn
    Artm1Verh/Y
Tg(Fabp4-cre)1Rev/0

involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       
adipose tissue
• while males on a normal chow diet are not obese, they show reduced perigonadal fat weight but increased interscapular brown adipose tissue at 3 months age (J:196857)
• however, body fat composition is no longer different by 6 months of age (J:196857)
• on a high-fat diet, males gain equal weight compared with controls, however after 24 weeks, they have more visceral fat, with increases in omental and mesenteric fat pad weights (J:196857)
• on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age (J:196857)
• however, white adipose tissue morphology in the perigonadal and subcutaneous depots are normal (J:196857)
• on a normal chow diet, males have reduced perigonadal fat weight and proportion (J:196857)
• after 24 weeks of a high-fat diet, males show an increase in mesenteric fat pad weight compared to controls (J:196857)
• after 24 weeks of a high-fat diet, males show an increase in omental fat pad weight compared to controls (J:196857)
• on a normal chow diet, males have an increase in interscapular brown adipose tissue at 3 months of age (J:196857)

growth/size
• on a normal chow diet, males gain less weight than controls at 3 months of age (J:196857)

homeostasis/metabolism
• males are euglycemic at 3 months of age, however between 3 and 12 months of age, males are unable to sustain the normal increase in insulin secretory capacity, and they develop hyperglycemia (J:196857)
• after 24 weeks on a high-fat diet, mutants have a poorer secretory response and become more hyperglycemic than controls (J:196857)
• males are euglycemic but hyperinsulinemic both in the fasted state and during glucose tolerance testing at 3 months of age (J:196857)
• 3 month old males have elevated plasma triglyceride levels but normal liver triglycerides (J:196857)
• males show age-related glucose intolerance (J:196857)
• insulin resistance in 3 month old males on a normal diet, as indicated by hyperinsulinemia both in the fasted state and during glucose tolerance (J:196857)

Mouse Models of Human Disease
OMIM IDRef(s)
Diabetes Mellitus, Noninsulin-Dependent; NIDDM 125853 J:196857