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Phenotypes Associated with This Genotype
Genotype
MGI:5502432
Allelic
Composition
Krastm1Bbd/Kras+
Trp53tm1Brd/Trp53+
Tg(Cela1-tTA)#Eps/?
Tg(tetO-cre)3Jig/?
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm1Bbd mutation (2 available); any Kras mutation (37 available)
Tg(Cela1-tTA)#Eps mutation (0 available)
Tg(tetO-cre)3Jig mutation (0 available)
Trp53tm1Brd mutation (6 available); any Trp53 mutation (155 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• all mice develop moderately to poorly differentiated pancreatic ductal adenocarcinomas, peritoneal explants, and perineural extensions

mortality/aging
• 50% mortality by 6 months of age
• 100% mortality by 1 year of age

neoplasm
• all mice develop moderately to poorly differentiated pancreatic ductal adenocarcinomas, peritoneal explants, and perineural extensions
• metastases develop affecting liver, diaphragm, lungs, lymph nodes, and spleen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
pancreatic carcinoma DOID:4905 OMIM:260350
J:119988


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory