Phenotypes Associated with This Genotype

Genotype
MGI:5502422

• Allelic Composition: Pkd1^tm1Ggg/Pkd1^tm2Ggg; Tg(Col1a1-cre)1Bek/0
• Genetic Background: involves: 129S4/SvJae * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Osteopenia in newborn Pkd1^tm1Ggg/Pkd1^tm2Ggg Tg(Col1a1-cre)1Bek/0 mice

mortality/aging

perinatal lethality ( J:191967 )

limbs/digits/tail

short femur ( J:191967 )

• newborns have short and less mineralized femurs

skeleton

short femur ( J:191967 )

• newborns have short and less mineralized femurs

decreased bone mineral density ( J:191967 )

• osteopenia is seen in newborns

decreased trabecular bone volume ( J:191967 )

• in newborns

decreased compact bone thickness ( J:191967 )

• in newborns

abnormal bone mineralization ( J:191967 )

• newborns show a delay in bone mineralization in calvarial and vertebral bone tissues

• bone phenotype is more severe than in Pkd1^tm1Ggg/Pkd1^tm1Ggg Tg(Col1a1-cre)1Bek/0 mice