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Phenotypes Associated with This Genotype
Genotype
MGI:5502225
Allelic
Composition
Ilktm1Star/Ilktm2Star
Tg(Acp5-cre)1Star/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ilktm1Star mutation (1 available); any Ilk mutation (18 available)
Ilktm2Star mutation (0 available); any Ilk mutation (18 available)
Tg(Acp5-cre)1Star mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• mice are phenotypically normal and show no differences in size or weight relative to controls at birth or throughout their lifespan

craniofacial
N
• animals have normal tooth eruption

skeleton
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also
• tibial bone volume is increased by 24% compared to controls at 6 weeks
• trabecular thickness of tibiae at 6 weeks is increased by 44% compared to controls

hematopoietic system
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also

immune system
• numbers of osteoclasts in the primary spongiosa are significantly increased at 6 weeks
• in vitro differentiated osteoclasts plate on dentin slices display decreased bone resorpion activity (45% lower osteoclastic resorption activity); osteoclasts show impaired resorption in vivo also


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory