Phenotypes Associated with This Genotype

Genotype
MGI:5501521

• Allelic Composition: Vdr^tm2.1Ska/Vdr^tm2.1Ska
• Genetic Background: involves: C57BL/6 * CBA/JNCrlj * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:196471 )

• mice die within 15 weeks of birth in mice fed a normal calcium diet

• however, high-calcium diets prevent lethality

skeleton

disorganized long bone epiphyseal plate ( J:196471 )

increased osteoid volume ( J:196471 )

abnormal bone ossification ( J:196471 )

• impaired bone formation

homeostasis/metabolism

decreased circulating calcium level ( J:196471 )

decreased circulating phosphate level ( J:196471 )

abnormal vitamin D level ( J:196471 )

• elevated serum levels of 1,25(OH)2D

growth/size/body

weight loss ( J:196471 )

• debilitated by weight loss after 9 weeks

postnatal growth retardation ( J:196471 )

integument

alopecia ( J:196471 )

endocrine/exocrine glands

increased activity of parathyroid ( J:196471 )

• secondary