Phenotypes Associated with This Genotype

Genotype
MGI:5501264

• Allelic Composition: Prkg1^tm1Hfm/Prkg1^tm1Hfm
• Genetic Background: involves: C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased brown adipose tissue amount ( J:199222 )

abnormal adipose tissue development ( J:199222 )

• impaired brown adipocyte differentiation

decreased brown fat cell lipid droplet size ( J:199222 )

decreased fat cell mitochondrial DNA content ( J:199222 )

• in vitro in differentiated adipocytes and in vivo

abnormal brown adipose tissue thermogenesis ( J:199222 )

• reduced

homeostasis/metabolism

decreased body surface temperature ( J:199222 )

• due to reduced brown adipose tissue thermogenic activity

decreased triglyceride level ( J:199222 )

• in interscapular brown adipose tissue

cellular

decreased fat cell mitochondrial DNA content ( J:199222 )

• in vitro in differentiated adipocytes and in vivo